From 2015, oil companies, including the Texas-based Oil Company Kosmos Energy, the Portuguese Galp Energy, British Petroleum (BP), French Total and Royal Dutch Shell have been actively acquiring oil blocks located in the STP EEZ.

Caterpillar, Avis car rental, and Coca-Cola have local STP agents.  

In order to do business in the archipelago, it is vital to visit STP and meet key players in the government.

STP is a member of several multi-lateral organizations, including the Economic Community of Central African States (ECCAS), Community of Portuguese Language Countries (CPLP).  STP is an eligible country under AGOA and has privilege to access the EU market through the “Tudo Menos Arma” (Everything but Arms) agreement in place until the conclusion of Economic Partnership Agreement (EPA) negotiations between African Caribbean and Pacific (ACP) countries and the EU. The archipelago is also an observer government at the World Trade Organization (WTO). STP also works with the World Bank, International Monetary Fund (IMF), and African Development Bank (AfDB). The archipelago is among the forty-four African Nations that signed the agreement of the African Continental Free Trade Area (AfCFTA) in March 2018 in Kigali, Rwanda, and became the 25th African country ratifying the AfCFTA in June 2019.