For U.S. businesses interested in doing business in Lesotho, it is important to have local presence by establishing branch offices, pursuing joint ventures with local businesses, or making use of sales agents.  It is worthwhile establishing business relationships before tender opportunities are announced.  U.S. firms should seek local partners with an existing reputation in their line of business or a complementary business.  Personal meetings with potential agents are encouraged, and due diligence is recommended to ensure that partners are reliable.  The U.S. Embassy encourages prospective U.S. investors to contact the National Development Corporation (LNDC), which plays a facilitating role for foreign investors, providing information to prospective investors, arranging site visits, helping with registration and licensing, and securing premises.

Lesotho has improved how it registers businesses, for example, in 2020, the World Bank reported  it took15 days to start a business in Lesotho.  However, after automating its systems, the Lesotho One Stop Business Facilitation Centre (OBFC) reports it takes a maximum of three days to register a business.